Cloud-based Liquid-biopsy and Radiomics Platform

Integrative analysis of multi-omics datasets is transforming cancer research and patient care. To fully utilize the petabyte-scale data within the Cancer Research Data Commons (CRDC), this project aims to seamlessly integrate EarlyDx’s liquid biopsy cloud-computing platform with CRDC data repositories. Liquid biopsies provide a non-invasive way to interrogate tumor genomic and epigenomic profiles. The co-analysis of CRDC datasets with user-provided blood data is expected to ensure broad user adoption of the CRDC.

Building on a successful Phase I prototype that integrated informatics tools with CRDC multi-omics datasets, the goal of this Phase II project is to:

• Finalize the Phase I prototype for multi-omics analysis.
• Expand the platform to integrate imaging data from the CRDC.
• Implement deep learning tools for integrative multi-omics and radiomics analysis.
• Implement diagnostic tools.
• Recruit at least 100 users for usability testing.

This cloud-based environment will facilitate multimodal analysis of methylation and imaging-derived features, with initial piloting focused on lung cancer. The platform's integration with CRDC will accelerate cancer research and promote clinical applications for cancer detection and treatment across broad populations.

Contact PI: William Hsu; Chun-Chi Liu (UCLA; EarlyDiagnostics, Inc.)

Funding Source: NIH NCI