Transportability analysis-a tool for extending trial results to a representative target population

"Randomized controlled trials estimate the causal effect between an intervention and the outcome on a target population through careful design to control for potential biases. However, this effect varies based on how the target population is defined, and in practice, physicians are tasked with determining the relevance of RCT results for patient populations with different characteristics than the study population. Approaches that extend inferences from a study population to a representative target, such as transportability analysis, provide powerful tools to address questions like who would most benefit from a clinical intervention."

doi.org/10.1001/jamanetworkopen.2023.46302 PMID: 38289608