Office Info

924 Westwood Blvd, Suite 420, Room K

William Speier, PhD

Assistant Professor, Department of Radiological Sciences


Robotics, natural language processing, and machine learning have made amazing advances over the past few decades, with significant time and funding dedicated to development of countless applications of these fields. Nevertheless, no machine-based system can match the versatility or robustness of the human brain; human-created language and image processing systems are vastly inferior to their biological counterparts; and human decisions and mechanical actions remain the gold standard in the medical field. The goal of my research is to bridge the gap between the brain and machine applications through:

  • Learning the underlying processes in the function of the human brain
  • Creating interfacing software to facilitate brain-machine interaction
  • Developing closed-loop systems to modulate patient treatment based on their physiological state

An example of a brain-computer interface project from our lab can be seen below:

Image removed.



Meng Y, Speier W, Ong M, Arnold CW. Multi-level embedding with topic modeling on electronic health records for predicting depression. Proc AAAI Health Intelligence Workshop. New York City, NY. February 7-12, 2020.


Sohn A, Speier W, Lan E, Aoki K, Fonarow G, Ong M, Arnold CW. Assessment of Heart Failure Patients' Interest in Mobile Health Apps for Self-Care: Survey Study. JMIR Cardio. 2019 Oct 29;3(2):e14332. DOI: 10.2196/14332. PMID: 31758788; PMCID: PMC6851712.
Meng Y, Speier W, Shufelt C, Joung S, E Van Eyk J, Bairey Merz CN, Lopez M, Spiegel B, Arnold CW. A Machine Learning Approach to Classifying Self-Reported Health Status in a Cohort of Patients With Heart Disease Using Activity Tracker Data. IEEE J Biomed Health Inform. 2020 Mar;24(3):878-884. DOI: 10.1109/JBHI.2019.2922178. Epub 2019 Jun 11. PMID: 31199276; PMCID: PMC6904535.
Li J, Li W, Gertych A, Knudsen BS, Speier W, Arnold CW. An attention-based multi-resolution model for prostate whole slide image classification and localization. arXiv preprint arXiv:1905.13208. 2019 May 30.
Li W, Wang Z, Yue Y, Li J, Speier W, Zhou M, Arnold CW. Semi-supervised Learning using Adversarial Training with Good and Bad Samples. arXiv preprint arXiv:1910.08540. 2019 Oct 18.

Li W, Wang Z, Li J, Polson J, Speier W, Arnold CW. Semi-supervised learning based on generative adversarial network: a comparison between good GAN and bad GAN approach. arXiv preprint arXiv:1905.06484. 2019 May 16.

Petousis P, Winter A, Speier W, Aberle DR, Hsu W, Bui AAT. Using Sequential Decision Making to Improve Lung Cancer Screening Performance. IEEE Access. 2019;7:119403-119419. doi: 10.1109/ACCESS.2019.2935763. Epub 2019 Aug 16. PMID: 32754420; PMCID: PMC7402617.


Li J, Speier W, Ho KC, Sarma KV, Gertych A, Knudsen BS, Arnold CW. An EM-based semi-supervised deep learning approach for semantic segmentation of histopathological images from radical prostatectomies. Comput Med Imaging Graph. 2018 Nov;69:125-133. DOI: 10.1016/j.compmedimag.2018.08.003. Epub 2018 Sep 3. PMID: 30243216; PMCID: PMC6173982.
Speier W, Arnold CW, Chandravadia N, Roberts D, Pendekanti S, Pouratian N. Improving P300 Spelling Rate using Language Models and Predictive Spelling. Brain Comput Interfaces (Abingdon). 2018;5(1):13-22. DOI: 10.1080/2326263X.2017.1410418. Epub 2017 Dec 26. PMID: 30560145; PMCID: PMC6294452PDF
Speier W, Dzubur E, Zide M, Shufelt C, Joung S, Van Eyk JE, Bairey Merz CN, Lopez M, Spiegel B, Arnold CW. Evaluating utility and compliance in a patient-based eHealth study using continuous-time heart rate and activity trackers. J Am Med Inform Assoc. 2018 Oct 1;25(10):1386-1391. DOI: 10.1093/jamia/ocy067. PMID: 29850807; PMCID: PMC6188512. PDF

Research Projects